Document Type : Research paper
Department of physics, Faculty of Science, University of Guilan, B. O. Box 14395-836, Rasht, Iran
The effective dose is an important tool in the radiation protection community because it represents the health risk associated with different procedures involving ionizing radiation, and therefore it allows comparing them. Therefore, accurate determination of the effective dose for nuclear medicine procedures is important. In this study, the effective dose per unit activity administered was calculated for some of the 99mTc-based radiopharmaceuticals. The MIRD method was used for the calculation of organ’s absorbed doses using the ICRP 110 adult male and female reference phantoms. The biokinetic data was taken from the ICRP Publications 128 and 53. Then, the effective doses were calculated using the ICRP 103 tissue weighting factors. The results show that with some exceptions, the calculated effective doses using new phantoms and tissue weighting factors are lower than the ICRP published data. This reduction is significant in some cases and can significantly reduce the collective effective dose of patients.
- The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103. Annals of the ICRP. 2007; 37 (2-4): 1-332.
- Andersson M, Johansson L, Minarik D, Leide-Svegborn S, Mattsson S. Effective dose to adult patients from 338 radiopharmaceuticals estimated using ICRP biokinetic data, ICRP/ICRU computational reference phantoms and ICRP 2007 tissue weighting factors. EJNMMI Phys. 2014; 1(1): 1-9.
- Hadid L, Gardumi A, Desbrée A. Evaluation of absorbed and effective doses to patients from radiopharmaceuticals using the ICRP 110 reference computational phantoms and ICRP 103 formulation. Radiat Prot Dosimetry. 2013; 156(2): 141-159.
- Radiation Dose to Patients from Radiopharmaceuticals. ICRP Publication 53. Annals of the ICRP. 1988; 18 (1-4):1-377.
- Radiation Dose to Patients from Radiopharmaceuticals. ICRP Publication 80 (Addendum 2 to ICRP Publication 53). Annals of the ICRP. 1998; 28:1-126.
- Radiation Dose to Patients from Radiopharmaceuticals. ICRP publication 106 (Addendum 3 to ICRP Publication 53). Annals of the ICRP. 2008; 38:1-197.
- Radiation Dose to Patients from Radiopharmaceuticals: A Compendium of Current Information Related to Frequently Used Substances. ICRP Publication 128. Annals of the ICRP. 2015; 44;7-321.
- Adult Reference Computational Phantoms. ICRP Publication 110. Annals of the ICRP. 2009; 39:1-162.
- Cristy M, Eckerman KF. Specific absorbed fractions of energy at various ages from internal photon sources. ORNL/TM 8381. 1987;V 1-7.
- Bolch WE, Eckerman KF, Sgouros G, Thomas SR. A generalized schema for radiopharmaceutical dosimetry--standardization of nomenclature. MIRD pamphlet No. 21. J Nucl Med. 2009; 50(3): 477-484.
- OpenGATE collaboration. http://www.opengatecollaboration.org.